We determined bootstrap P beliefs with the Q
We determined bootstrap P beliefs with the Q x statistic (73) by recomputing the statistic for random sets of SNPs in matched 5% derived allele frequency bins (polarized using the chimpanzee reference gnome panTro2). For each bootstrap replicate, we keep the original effect sizes but replace the frequencies of each SNP with one randomly sampled from the same bin. Unlike the PRS calculations, we ignored missing data, since the Qx statistic uses only the population-level estimated allele frequencies and not individual-level data. We tested a series of nested sets of SNPs (x axis…Read more …
